Novel Developments in the Epidemic of Human Immunodeficiency Virus and Tuberculosis Coinfection

被引：18

作者：

Anandaiah, Asha ^{[1
]}

Dheda, Keertan ^{[2
,3
,4
,5
,6
]}

Keane, Joseph ^{[7
,8
]}

Koziel, Henry ^{[1
]}

Moore, David A. J. ^{[9
]}

Patel, Naimish R. ^{[1
]}

机构：

[1] Harvard Univ, Div Pulm Crit Care & Sleep Med, Beth Israel Deaconess Med Ctr, Sch Med,Dept Med, Boston, MA 02215 USA

[2] Univ Cape Town, Dept Med, Div Pulmonol, ZA-7925 Cape Town, South Africa

[3] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

[4] Univ Cape Town, Lung Inst, Lung Infect & Immun Unit, ZA-7925 Cape Town, South Africa

[5] Univ Cape Town, Lung Inst, Ctr TB Res & Innovat, ZA-7925 Cape Town, South Africa

[6] UCL, Sch Med, Ctr Infect Dis & Int Hlth, London, England

[7] Trinity Coll Dublin, Dept Clin Med, Inst Mol Med, Dublin, Ireland

[8] St James Hosp, Dublin, Ireland

[9] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1, England

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2011年 / 183卷 / 08期

关键词：

tuberculosis; HIV; diagnosis; management; epidemiology; HIV-INFECTED PATIENTS; ISONIAZID PREVENTIVE THERAPY; RECONSTITUTION INFLAMMATORY SYNDROME; MULTIDRUG-RESISTANT TUBERCULOSIS; DRUG-SUSCEPTIBILITY ASSAY; GAMMA RELEASE ASSAY; CELL-BASED ASSAYS; CD4; T-CELLS; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS;

D O I：

10.1164/rccm.201008-1246CI

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Tuberculosis (TB) disease remains one of the highest causes of mortality in HIV-infected individuals, and HIV-TB coinfection continues to grow at alarming rates, especially in sub-Saharan Africa. Surprisingly, a number of important areas regarding coinfection remain unclear. For example, increased risk of TB disease begins early in the course of HIV infection; however, the mechanism by which HIV increases this risk is not well understood. In addition, there is lack of consensus on the optimal way to diagnose latent TB infection and to manage active disease in those who are HIV infected. Furthermore, effective point-of-care testing for TB disease remains elusive. This review discusses key areas in the epidemiology, pathogenesis, diagnosis, and management of active and latent TB in those infected with HIV, focusing attention on issues related to high-and low-burden areas. Particular emphasis is placed on controversial areas where there are gaps in knowledge and on future directions of study.

引用

页码：987 / 997

页数：11

共 145 条

[1] Detection and Prediction of Active Tuberculosis Disease by a Whole-Blood Interferon-γ Release Assay in HIV-1-Infected Individuals [J].