Mechanisms of platelet aggregation

被引:103
作者
Savage, B
Cattaneo, M
Ruggeri, ZM
机构
[1] Scripps Res Inst, Div Expt Hemostasis & Thrombosis, Dept Mol & Expt Med, Roon Res Ctr Arteriosclerosis & Thrombosis, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA
[3] Univ Milan, Osped Maggiore, Ist Ric & Cura Carattere Sci,Dept Internal Med, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, Milan, Italy
关键词
D O I
10.1097/00062752-200109000-00002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alpha (IIb)beta (3). Recent advances in the study of platelet receptors for Collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation. Curr Opin Hematol 2001, 8:270-276 (C) 2001 Lippincott Williams & Wilkins, Inc.
引用
收藏
页码:270 / 276
页数:7
相关论文
共 96 条
[1]  
Alberio L, 1999, EUR J CLIN INVEST, V29, P1066
[2]  
ALBERIO L, 1988, BRIT J HAEMATOL, V102, P1212
[3]  
AZUMA H, 1993, THROMB HAEMOSTASIS, V69, P192
[4]  
Barnes M J, 1998, Curr Opin Hematol, V5, P314, DOI 10.1097/00062752-199809000-00002
[5]   Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets [J].
Bauer, M ;
Retzer, M ;
Wilde, JI ;
Maschberger, P ;
Essler, M ;
Aepfelbacher, M ;
Watson, SP ;
Siess, W .
BLOOD, 1999, 94 (05) :1665-1672
[6]   IDENTIFICATION OF ASPARTIC ACID-514 THROUGH GLUTAMIC ACID-542 AS A GLYCOPROTEIN-IB-IX COMPLEX RECEPTOR RECOGNITION SEQUENCE IN VONWILLEBRAND-FACTOR - MECHANISM OF MODULATION OF VONWILLEBRAND-FACTOR BY RISTOCETIN AND BOTROCETIN [J].
BERNDT, MC ;
WARD, CM ;
BOOTH, WJ ;
CASTALDI, PA ;
MAZUROV, AV ;
ANDREWS, RK .
BIOCHEMISTRY, 1992, 31 (45) :11144-11151
[7]   NEW STRUCTURAL MOTIF FOR LIGAND-GATED ION CHANNELS DEFINED BY AN IONOTROPIC ATP RECEPTOR [J].
BRAKE, AJ ;
WAGENBACH, MJ ;
JULIUS, D .
NATURE, 1994, 371 (6497) :519-523
[8]  
BRASS LF, 1992, J BIOL CHEM, V267, P13795
[9]  
CATTANEO M, 1990, BLOOD, V75, P1081
[10]  
Cattaneo M, 1997, THROMB HAEMOSTASIS, V77, P986