Activity-induced enhancement of HB-GAM expression in rat hippocampal slices

被引：29

作者：

Lauri, SE

Taira, T

Kaila, K

Rauvala, H

机构：

[1] UNIV HELSINKI,INST BIOTECHNOL,MOL NEUROBIOL LAB,FIN-00014 HELSINKI,FINLAND

[2] UNIV HELSINKI,DEPT PHYSIOL,INST BIOMED,FIN-00014 HELSINKI,FINLAND

来源：

NEUROREPORT | 1996年 / 7卷 / 10期

关键词：

activity-dependent gene expression; heparin-binding growth-associated molecule; hippocampus; longterm potentiation; synaptic plasticity;

D O I：

10.1097/00001756-199607080-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HEPARIN-BINDING growth-associated molecule (HB-GAM) is a developmentally regulated secretory protein with neurite outgrowth-promoting activity. High-frequency stimulation leading to induction of long-term potentiation (LTP) resulted in increased expression of HB-GAM in rat hippocampal area CA1. When tetanization was given in the presence of antagonists of the N-methyl-D-aspartate (NMDA) receptor and postsynaptic voltage-gated calcium channels, the mRNA level was comparable to control levels. The results indicate that high frequency stimulation inducing LTP results in calcium-dependent enhancement in HB-GAM expression, and imply a role for this extracellular protein in the modulation of synaptic function in the hippocampus.

引用

页码：1670 / 1674

页数：5

共 20 条

[1] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].