A method for the synthesis of hydroxamic acids on solid phase

被引：93

作者：

Floyd, CD

Lewis, CN

Patel, SR

Whittaker, M

机构：

[1] British Biotech Pharmaceutical Ltd, Oxford, OX4 5LY, Watlington Rd

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 44期

关键词：

D O I：

10.1016/0040-4039(96)01821-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Wang resin 1 was modified using a Mitsunobu reaction to give resin bound O-hydroxylamine 3. This resin was acylated and the adduct cleaved from the resin as a hydroxamic acid on treatment with TFA. Series of tripeptide, and sulfonamido 9 hydroxamic acids which act as inhibitors of metalloproteinases have been prepared. Resins more sensitive to acid cleavage can also be modified to simplify the work-up procedure. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8045 / 8048

页数：4

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