Imaging of stem cells using MRI

被引：96

作者：

Kraitchman, Dara L. ^{[1
,2
]}

Bulte, Jeff W. M. ^{[1
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Inst Computat Med, Inst NanoBiotechnol, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Chem & Biomol Engn, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Cellular Imaging Sect & Vasc Biol Program, Baltimore, MD 21287 USA

来源：

BASIC RESEARCH IN CARDIOLOGY | 2008年 / 103卷 / 02期

关键词：

stem cells; magnetic resonance imaging; superparamagnetic iron oxides; myocardial infarction; reporter gene;

D O I：

10.1007/s00395-008-0704-5

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The administration of exogenous stem cells offers promise to regenerate many damaged organs. However, failures of these cellular therapies could be related to many issues, such as the type of stem cell, the dose of cellular therapeutic, dosing regime, and mode of delivery. The recent ability to directly label stem cells with magnetic resonance (MR) contrast agents provides a simple, straight-forward manner to monitor accurate cell delivery and track stem cells non-invasively in a serial manner. Provided here is an overview of the currently available MR-labeling methods, including direct non-specific labeling with contrast agents, indirect specific labeling with contrast agents, labeling with MRI reporter genes, and fluorine hot spot labeling. Several of these approaches have now been applied successfully in preclinical animal models of cardiovascular disease. Once properly implemented, future clinical trials may benefit greatly from imaging stem cells with MRI.

引用

页码：105 / 113

页数：9

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