Suppression of c-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells

被引：66

作者：

Guo, Junming ^{[1
]}

Xiao, Bingxiu ^{[1
]}

Liu, Qiong ^{[1
]}

Gong, Zhaohui ^{[1
]}

Le, Yanping ^{[1
]}

机构：

[1] Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 04期

关键词：

stomach cancer; aloe-emodin; cell growth; c-myc;

D O I：

10.1080/07357900701788130

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Aloe-emodin is a hydroxyanthraquinone found in Aloe vera, as well as in leaves and roots of other plants. The mechanisms of its anticancer effect are largely unknown. The present study investigated its molecular mechanisms. Crystal violet assay showed that aloe-emodin had a long-term anti-proliferation effect on human gastric cancer MGC-803 and SGC-7901 cells. Scratch wound-healing motility assays indicated its anti-migration effect. Aloe-emodin arrested SGC-7901 cells at G2/M phase. More importantly, aloe-emodin inhibited the expressions of protein kinase C and c-myc. In conclusion, the anticancer effect of aloe-emodin on gastric cancer cells involves suppression of c-myc expression.

引用

页码：369 / 374

页数：6

共 26 条

[1]

Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells [J].