New molecular insights into CETP structure and function: a review

被引：63

作者：

Charles, M. Arthur ^{[1
]}

Kane, John P. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Sch Med, Cardiovasc Res Inst, San Francisco, CA 94158 USA

来源：

JOURNAL OF LIPID RESEARCH | 2012年 / 53卷 / 08期

关键词：

molecular biology of CETP; functional domains of CETP; lipid transfer biology; lipid transfer tunnel hypothesis; CHOLESTERYL ESTER-TRANSFER; HIGH-DENSITY-LIPOPROTEINS; APOLIPOPROTEIN-A-I; HUMAN-PLASMA LOW; TRANSFER INHIBITOR PROTEIN; LIPID TRANSFER PROTEIN; APOLIPOPHORIN-III; EXCHANGEABLE APOLIPOPROTEIN; RESONANCE-SPECTROSCOPY; PHOSPHOLIPID-VESICLES;

D O I：

10.1194/jlr.R027011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cholesteryl ester transfer protein (CETP) is important clinically and is the current target for new drug development. Its structure and mechanism of action has not been well understood. We have combined current new structural and functional methods to compare with relevant prior data. These analyses have led us to propose several steps in CETP's function at the molecular level, in the context of its interactions with lipoproteins, e.g., sensing, penetration, docking, selectivity, ternary complex formation, lipid transfer, and HDL dissociation.(jlr) These new molecular insights improve our understanding of CETP's mechanisms of action.-Charles, M. A., and J. P. Kane. New molecular insights into CETP structure and function: a review. J. Lipid Res. 2012. 53: 1451-1458.

引用

页码：1451 / 1458

页数：8

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