Absolute linkage of celiac disease and dermatitis herpetiformis to HLA-DQ

被引：49

作者：

Balas, A

Vicario, JL

Zambrano, A

Acuna, D

GarciaNovo, D

机构：

[1] CTR TRANSFUS,LAB HISTOCOMPATIBILIDAD,E-28009 MADRID,SPAIN

[2] NINO JESUS HOSP,DEPT DERMATOL,MADRID,SPAIN

[3] NINO JESUS HOSP,DEPT GASTROENTEROL,MADRID,SPAIN

来源：

TISSUE ANTIGENS | 1997年 / 50卷 / 01期

关键词：

celiac disease; dermatitis herpetiformis; HLA-DQ; Spanish population;

D O I：

10.1111/j.1399-0039.1997.tb02834.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This report shows the absolute genetic linkage of celiac disease (CD) to the HLA-DQ region, and supports the fact that dermatitis herpetiformis (DH) follows the same pattern of HLA-mediated susceptibility in extensive series of Caucasian Spanish patients. Ninety-five percent of CD (201 of 212) and 100% of DH (55) patients could produce DQ alpha 1*0501-DQ beta 1*02 heterodimers. Negative CD patients for this combination were mostly DR4-DQ8 (DQA1*03-DQB1*0302) (9 of 11), along with a restricted number of complementary chromosomes. Comparison of observed and expected DQA1-DQB1 genotype distributions (Hardy-Weinberg equilibrium) showed that the excess of patients with DQB1*02 in double doses would be the consequence for which this allele should be complemented by DQA1*0501. Homozygosity for DQA1*0501 would restrain susceptibility to CD and DH.

引用

页码：52 / 56

页数：5

共 30 条

[1] MAJOR HISTOCOMPATIBILITY COMPLEX SUSCEPTIBILITY GENES FOR DERMATITIS-HERPETIFORMIS COMPARED WITH THOSE FOR GLUTEN-SENSITIVE ENTEROPATHY [J].