Regioselective formation, using orthogonal cysteine protection, of an α-conotoxin dimer peptide containing four disulfide bonds

被引：53

作者：

Cuthbertson, A ^{[1
]}

Indrevoll, B ^{[1
]}

机构：

[1] Amersham Hlth AS, Dept Med Chem, Oslo, Norway

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 16期

关键词：

D O I：

10.1021/ol035105w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of the cysteine thiol protecting groups Trt, Acm, tBu, and MeBzl were used for the regioselective formation of an alpha-conotoxin dimer peptide containing four disulfide bridges. Additionally, a protocol is described whereby two one-pot oxidations were employed in order to improve the efficiency of the folding process. The target compound was produced in good yield.

引用

页码：2955 / 2957

页数：3

共 11 条

[1]

Annis I, 1997, METHOD ENZYMOL, V289, P198

[2]

Atherton E, 1989, SOLID PHASE SYNTHESI

[3] TERTIARY BUTYL GROUP AS A BLOCKING AGENT FOR HYDROXYL, SULFHYDRYL AND AMIDO FUNCTIONS IN PEPTIDE SYNTHESIS [J].