Towards patient-based cancer therapeutics

被引:55
作者
Schreiber, Stuart L. [1 ]
Shamji, Alykhan F. [1 ]
Clemons, Paul A. [1 ]
Hon, Cindy [1 ]
Koehler, Angela N. [1 ]
Munoz, Benito [1 ]
Palmer, Michelle [1 ]
Stern, Andrew M. [1 ]
Wagner, Bridget K. [1 ]
Powers, Scott [2 ]
Lowe, Scott W. [2 ]
Guo, Xuecui [2 ]
Krasnitz, Alex [2 ]
Sawey, Eric T. [2 ]
Sordella, Raffaella [2 ]
Stein, Lincoln [2 ]
Trotman, Lloyd C. [2 ]
Califano, Andrea [3 ]
Dalla-Favera, Riccardo [3 ]
Ferrando, Adolfo [3 ]
Iavarone, Antonio [3 ]
Pasqualucci, Laura [3 ]
Silva, Jose [3 ]
Stockwell, Brent R. [3 ]
Hahn, William C. [4 ]
Chin, Lynda [4 ]
DePinho, Ronald A. [4 ]
Boehm, Jesse S. [4 ]
Gopal, Shuba [4 ]
Huang, Alan [4 ]
Root, David E. [4 ]
Weir, Barbara A. [4 ]
Gerhard, Daniela S. [5 ]
Zenklusen, Jean Claude [5 ]
Roth, Michael G. [6 ]
White, Michael A. [6 ]
Minna, John D. [6 ]
MacMillan, John B. [6 ]
Posner, Bruce A. [6 ]
机构
[1] Harvard & MIT, Broad Inst, Cambridge, MA USA
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[3] Columbia Univ, New York, NY USA
[4] Dana Farber Canc Inst, Cambridge, MA USA
[5] US Natl Canc Inst, Bethesda, MD USA
[6] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
关键词
ONCOGENE ADDICTION; LIVER-CANCER; CELL-LINES; STEM-CELLS; IDENTIFICATION; GENOTYPE; THERAPY; MODELS; TUMORS;
D O I
10.1038/nbt0910-904
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.
引用
收藏
页码:904 / 906
页数:3
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