Turning on a dimer: New insights into MLL chimeras

被引：10

作者：

Hsu, K ^{[1
]}

Look, AT ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CANCER CELL | 2003年 / 4卷 / 02期

关键词：

D O I：

10.1016/S1535-6108(03)00192-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, So et al. (2003) demonstrate a novel mechanism for the oncogenic activity of MILL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MILL fusion proteins donate a platform for MILL homodimerization, allowing recruitment of accessory factors needed to activate the critical downstream targets, including selected subsets of the major HOX genes.

引用

页码：81 / 83

页数：3

共 14 条

[1] MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia [J].

Armstrong, SA ;

Staunton, JE ;

Silverman, LB ;

Pieters, R ;

de Boer, ML ;

Minden, MD ;

Sallan, SE ;

Lander, ES ;

Golub, TR ;

Korsmeyer, SJ .

NATURE GENETICS, 2002, 30 (01) :41-47

[2]

AYTON PM, 2003, IN PRESS GENES DEV

[3] Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias:: dominance of HOX dysregulation [J].

Ferrando, AA ;

Armstrong, SA ;

Neuberg, DS ;

Sallan, SE ;

Silverman, LB ;

Korsmeyer, SJ ;

Look, AT .

BLOOD, 2003, 102 (01) :262-268

[4] Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization [J].

Hsieh, JJD ;

Ernst, P ;

Erdjument-Bromage, H ;

Tempst, P ;

Korsmeyer, SJ .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (01) :186-194

[5] Oncogenic transcription factors in the human acute leukemias [J].

Look, AT .

SCIENCE, 1997, 278 (5340) :1059-1064

[6] Paralogous Hox genes: Function and regulation [J].

Maconochie, M ;

Nonchev, S ;

Morrison, A ;

Krumlauf, R .

ANNUAL REVIEW OF GENETICS, 1996, 30 :529-556

[7] MLL targets SET domain methyltransferase activity to Hox gene promoters [J].

Milne, TA ;

Briggs, SD ;

Brock, HW ;

Martin, ME ;

Gibbs, D ;

Allis, CD ;

Hess, JL .

MOLECULAR CELL, 2002, 10 (05) :1107-1117

[8] ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation [J].

Nakamura, T ;

Mori, T ;

Tada, S ;

Krajewski, W ;

Rozovskaia, T ;

Wassell, R ;

Dubois, G ;

Mazo, A ;

Croce, CM ;

Canaani, E .

MOLECULAR CELL, 2002, 10 (05) :1119-1128

[9] DIFFERENTIAL EXPRESSION OF HOMEOBOX GENES IN FUNCTIONALLY DISTINCT CD34(+) SUBPOPULATIONS OF HUMAN BONE-MARROW CELLS [J].

SAUVAGEAU, G ;

LANSDORP, PM ;

EAVES, CJ ;

HOGGE, DE ;

DRAGOWSKA, WH ;

REID, DS ;

LARGMAN, C ;

LAWRENCE, HJ ;

HUMPHRIES, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) :12223-12227

[10] ALL-1 PARTIAL DUPLICATION IN ACUTE-LEUKEMIA [J].

SCHICHMAN, SA ;

CALIGIURI, MA ;

GU, YS ;

STROUT, MP ;

CANAANI, E ;

BLOOMFIELD, CD ;

CROCE, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :6236-6239

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