Endothelial and Microcirculatory Function and Dysfunction in Sepsis

被引：112

作者：

Colbert, James F. ^{[1
]}

Schmidt, Eric P. ^{[2
]}

机构：

[1] Univ Colorado, Sch Med, Div Infect Dis, Dept Med, 12700 E 19th Ave, Aurora, CO 80045 USA

[2] Univ Colorado, Div Pulm Sci & Crit Care Med, Dept Med, Denver Hlth Med Ctr,Sch Med, 12700 E 19th Ave, Aurora, CO 80045 USA

来源：

CLINICS IN CHEST MEDICINE | 2016年 / 37卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Sepsis; Microcirculation; Glycocalyx; Intravital microscopy; Glycosaminoglycans; Heparan sulfate; GOAL-DIRECTED RESUSCITATION; MICROVASCULAR BLOOD-FLOW; SEPTIC SHOCK; NITRIC-OXIDE; GLYCOCALYX PERMEABILITY; HYDROXYETHYL STARCH; CAPILLARY PERFUSION; CONTROLLED-TRIAL; OXYGEN DELIVERY; DOUBLE-BLIND;

D O I：

10.1016/j.ccm.2016.01.009

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The microcirculation is a series of arterioles, capillaries, and venules that performs essential functions of oxygen and nutrient delivery, customized to the unique physiologic needs of the supplied organ. The homeostatic microcirculatory response to infection can become harmful if overactive and/or dysregulated. Pathologic micro circulatory dysfunction can be directly visualized by intravital microscopy or indirectly measured via detection of circulating biomarkers. Although several treatments have been shown to protect the microcirculation during sepsis, they have not improved patient outcomes when applied indiscriminately. Future outcomes-oriented studies are needed to test sepsis therapeutics when personalized to a patient's microcirculatory dysfunction.

引用

页码：263 / +

页数：14

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