Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element

被引：15

作者：

Dailly, YP

Zhou, YH

Linkhart, TA

Baylink, DJ

Strong, DD

机构：

[1] Jerry L Pettis Mem Vet Adm Med Ctr, Musculoskeletal Dis Ctr 151, Loma Linda, CA 92357 USA

[2] Loma Linda Univ, Dept Med, Loma Linda, CA 92357 USA

[3] Dept Biochem, Loma Linda, CA 92357 USA

[4] Loma Linda Univ, Dept Microbiol & Mol Genet, Loma Linda, CA 92357 USA

[5] Loma Linda Univ, Dept Pediat, Loma Linda, CA 92357 USA

[6] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2001年 / 1518卷 / 1-2期

关键词：

transcription; osteoblast; retinoic acid; promoter;

D O I：

10.1016/S0167-4781(01)00192-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5'-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription start sites and three retinoic acid response elements (RAREs) with widely spaced half-sites. Only the proximal DR15 RARE was functional. Retinoids increased IGFBP-6 promoter activity up to 3-fold. (C) 2001 Published by Elsevier Science B.V.

引用

页码：145 / 151

页数：7

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