The chemistry of phosphate esters.

被引:29
作者
Domingos, JB [1 ]
Longhinotti, E [1 ]
Machado, VG [1 ]
Nome, F [1 ]
机构
[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
来源
QUIMICA NOVA | 2003年 / 26卷 / 05期
关键词
phosphate esters; nerve agents; enzymatic models;
D O I
10.1590/S0100-40422003000500019
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
THE CHEMISTRY OF PHOSPHATE ESTERS. This work summarizes important aspects of the chemistry of phosphate esters, with special emphasis on: i) advances in the design of enzymatic models for phosphatases; and ii) nerve agents and currently used strategies for detoxification. The physical organic chemical aspects that are responsible by the reactivity of phosphate esters are also discussed.
引用
收藏
页码:745 / 753
页数:9
相关论文
共 90 条
[1]  
[Anonymous], BIOORGANIC MECHANISM
[2]  
[Anonymous], 1996, Bioorganic Chemistry: A Chemical Approach to Enzyme Action
[3]  
[Anonymous], GAS BATTLE YPRES 191
[4]   Mechanistic alternatives phosphate monoester hydrolysis:: what conclusions can be drawn from available experimental data? [J].
Åqvist, J ;
Kolmodin, K ;
Florian, J ;
Warshel, A .
CHEMISTRY & BIOLOGY, 1999, 6 (03) :R71-R80
[5]  
BELETSKAYA IP, 1995, VESTN ROS AKAD NAUK+, V65, P99
[6]   NERVE AGENT STEREOISOMERS - ANALYSIS, ISOLATION, AND TOXICOLOGY [J].
BENSCHOP, HP ;
DEJONG, LPA .
ACCOUNTS OF CHEMICAL RESEARCH, 1988, 21 (10) :368-374
[7]   Recent studies of nucleophilic, general-acid, and metal ion catalysis of phosphate diester hydrolysis [J].
Blaskó, A ;
Bruice, TC .
ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (06) :475-484
[8]   CLEAVAGE OF PHOSPHATE-ESTERS BY A CYCLODEXTRIN DIMER CATALYST THAT BINDS THE SUBSTRATES TOGETHER WITH LA3+ AND HYDROGEN-PEROXIDE [J].
BRESLOW, R ;
ZHANG, BL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (17) :7893-7894
[9]   BIOMIMETIC CHEMISTRY AND ARTIFICIAL ENZYMES - CATALYSIS BY DESIGN [J].
BRESLOW, R .
ACCOUNTS OF CHEMICAL RESEARCH, 1995, 28 (03) :146-153
[10]   CHEMISTRY OF PHOSPHODIESTERS, DNA AND MODELS .2. THE HYDROLYSIS OF BIS(8-HYDROXYQUINOLINE) PHOSPHATE IN THE ABSENCE AND PRESENCE OF METAL-IONS [J].
BROWNE, KA ;
BRUICE, TC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (13) :4951-4958