How sigma docks to RNA polymerase and what sigma does

被引：117

作者：

Burgess, RR ^{[1
]}

Anthony, L ^{[1
]}

机构：

[1] Univ Wisconsin, McArdle Lab Canc Res, Madison, WI 53706 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 02期

关键词：

D O I：

10.1016/S1369-5274(00)00177-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It is clear that multiple sites of interaction exist between sigmas and core subunits, likely reflecting the changing pattern of interactions that occur sequentially during the complex process of holoenzyme formation, open promoter formation, and initiation of transcription. Recent studies have revealed that a major site of interaction of Escherichia coli sigma factors is the amino acid 260-309 coiled-coil region of the beta ' subunit of core RNA polymerase. This region of beta ' interacts with region 2.1-2.2 of sigma (70), Binding of this region of beta ' to sigma (70) triggers a conformational change in sigma that allows it to bind to a -10 nontemplate promoter DNA strand oligonucleotide.

引用

页码：126 / 131

页数：6

共 55 条

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