Alumina catalyzed synthesis of fused thioxopyrimidine derivatives under microwaves

被引：17

作者：

Kidwai, M ^{[1
]}

Mohan, R ^{[1
]}

Rastogi, S ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 21期

关键词：

alumina; catalyst; solid support; microwave irradiation; thioxopyrimidines; dry media;

D O I：

10.1081/SCC-120025184

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expeditious solventless approach for the synthesis of pyrazolino[3,4-d]/isoxazolino[3,4-d]/pyrano[2,3-d]/iminopyrimidino[4,5-d]/thioxopyrimidino[4,5-d]/thiazino[5,4-d] pyrimidines from 2-thiobarbituric acid using supported reagents (acidic/basic alumina) under microwave irradiation (MWI) is described. The reaction times were brought down from hours to minutes with yield enhancement. Also the procedure highlights the versatility of solid supports.

引用

页码：3747 / 3759

页数：13

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