Anti-inflammatory therapeutics for the treatment of atherosclerosis

被引：253

作者：

Charo, Israel F. ^{[1
]}

Taub, Rebecca ^{[2
]}

机构：

[1] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] VIA Pharmaceut, Res & Dev, Ft Washington, PA 19034 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2011年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

C-REACTIVE PROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SMOOTH-MUSCLE-CELLS; CARDIOVASCULAR-DISEASE; 5-LIPOXYGENASE PATHWAY; MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEIN; ADHESION MOLECULES; CHOLESTEROL EFFLUX; PROMOTER GENOTYPE;

D O I：

10.1038/nrd3444

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Atherosclerosis is the primary cause of heart disease and stroke and is thus the underlying pathology of the leading causes of death in the western world. Although risk can be reduced by lowering lipid levels, the equally important contribution of inflammation to the development of cardiovascular disease is not adequately addressed by existing therapies. Here, we summarize the evidence supporting a role for inflammation in the pathogenesis of atherosclerosis, discuss agents that are currently in the clinic and provide a perspective on the challenges faced in the development of drugs that target vascular inflammation.

引用

页码：365 / 376

页数：11

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