Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms

被引：62

作者：

Konno, K

Hisada, M

Itagaki, Y

Naoki, H

Kawai, N

Miwa, A

Yasuhara, T

Takayama, H ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa 1990195, Japan

[2] Suntory Inst Bioorgan Res, Osaka 6188503, Japan

[3] Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 3290498, Japan

[4] Tokyo Metropolitan Inst Neurosci, Dept Neurobiol, Tokyo 1838526, Japan

[5] Tokyo Univ Agr, Jr Coll Agr, Dept Nutr, Setagaya Ku, Tokyo 1568502, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 250卷 / 03期

关键词：

D O I：

10.1006/bbrc.1998.9299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel peptide neurotoxins, alpha- and beta-pompilidotoxins (alpha- and beta-PMTXs), were purified from the venoms of the solitary wasps Anoplius samariensis and Batozonellus maculifrons. Their structures were analyzed mostly by MALDI-TOF-MS, which were corroborated by solid-phase synthesis. alpha-PMTX, with 13 amino acid residues and the sequence of Arg-Ile-Lys-Ile-Gly-Leu-Phe-Gln-Asp-Leu-Ser-Lys-Leu-NH(2), greatly potentiates synaptic transmission of lobster leg muscle by the presynaptic mechanisms. beta-PMTX, in which the lysine residue at 12 position of alpha-PMTX was replaced with arginine, was more potent than alpha-PMTX. (C) 1998 Academic Press.

引用

页码：612 / 616

页数：5

共 20 条

[1] EFFECTS OF A SPIDER TOXIN ON THE GLUTAMINERGIC SYNAPSE OF LOBSTER MUSCLE [J].