Machine perfusion for kidneys: how to do it at minimal cost

被引：24

作者：

Balupuri, S ^{[1
]}

Strong, A ^{[1
]}

Hoernich, N ^{[1
]}

Snowden, C ^{[1
]}

Mohamed, M ^{[1
]}

Manas, D ^{[1
]}

Kirby, J ^{[1
]}

Talbot, D ^{[1
]}

机构：

[1] Freeman Hosp, Renal & Liver Transplant Unit, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

来源：

TRANSPLANT INTERNATIONAL | 2001年 / 14卷 / 02期

关键词：

renal transplantation; machine perfusion; dialysis; non-heart-beating donor;

D O I：

10.1111/j.1432-2277.2001.tb00022.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Due to a shortage of organs for transplantation, many centres use marginal grafts to increase their donor pool. As kidneys from non-heart-beating donors (NHBD) have sustained initial ischaemic damage, their viability is difficult to predict. Hypothermic pulsatile perfusion has not only been used to improve the condition of such grafts, but also allows viability assessment. Suitable systems are becoming more readily available, but they are expensive. We have used existing dialysis equipment with modified sterilised inserts to create a pulsatile hypothermic perfusion system. With this system, 41 NHBD kidneys were perfused for up to 8 h; their intravascular renal resistance (IRVR), flow characteristics as well as glutathione S transferase (GST) measurements were performed to assess viability. This hypothermic pulsatile perfusion system is now an integral component of our NHBD programme.

引用

页码：103 / 107

页数：5

共 21 条

[1] SINGLE-DONOR COLD-STORAGE VERSUS MACHINE PERFUSION IN CADAVER KIDNEY-PRESERVATION
ALIJANI, MR
CUTLER, JA
DELVALLE, CJ
MORRES, DN
FAWZY, A
PECHAN, BW
HELFRICH, GB
[J]. TRANSPLANTATION, 1985, 40 (06) : 659 - 661
[2] GLUTATHIONE TRANSFERASE IN THE URINE - A MARKER FOR POST-TRANSPLANT TUBULAR LESIONS
BACKMAN, L
APPELKVIST, EL
RINGDEN, O
DALLNER, G
[J]. KIDNEY INTERNATIONAL, 1988, 33 (02) : 571 - 577
[3] Balupuri S, 2000, TRANSPLANTATION, V69, P842
[4] BARBER WH, 1991, TRANSPLANT P, V23, P2394
[5] National impact of pulsatile perfusion on cadaveric kidney transplantation
Burdick, JF
Rosendale, JD
McBride, MA
Kauffman, HM
Bennett, LE
[J]. TRANSPLANTATION, 1997, 64 (12) : 1730 - 1733
[6] Glutathione S-transferase as predictor of functional outcome in transplantation of machine-preserved non-heart-beating donor kidneys
Daemen, JWHC
Oomen, APA
Janssen, MA
vandeSchoot, L
vanKreel, BK
Heineman, E
Kootstra, G
[J]. TRANSPLANTATION, 1997, 63 (01) : 89 - 93
[7] SUCCESSFUL EXTRARENAL TRANSPLANTATION FROM NON-HEART-BEATING DONORS
DALESSANDRO, AM
HOFFMANN, RM
KNECHTLE, SJ
ECKHOFF, DE
LOVE, RB
KALAYOGLU, M
SOLLINGER, HW
BELZER, FO
[J]. TRANSPLANTATION, 1995, 59 (07) : 977 - 982
[8] A RANDOMIZED PROSPECTIVE TRIAL OF COLD-STORAGE VERSUS PULSATILE PERFUSION FOR CADAVER KIDNEY-PRESERVATION
HALLORAN, P
APRILE, M
[J]. TRANSPLANTATION, 1987, 43 (06) : 827 - 832
[9] Viability assessment of non-heart-beating donor kidneys by alpha glutathione S-transferase in the machine perfusate
Kievit, JK
Oomen, APA
Janssen, MA
vanKreel, BK
Heineman, E
Kootstra, G
[J]. TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) : 1381 - 1383
[10] KOOTSTRA G, 1991, TRANSPLANT P, V23, P910

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