Prophinder: a computational tool for prophage prediction in prokaryotic genomes

被引:158
作者
Lima-Mendez, Gipsi [1 ]
Van Helden, Jacques [1 ]
Toussaint, Ariane [1 ]
Leplae, Raphael [1 ]
机构
[1] Free Univ Brussels, Lab Bioinformat Genom & Reseaux BiGRe, B-1050 Brussels, Belgium
关键词
D O I
10.1093/bioinformatics/btn043
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Prophinder is a prophage prediction tool coupled with a prediction database, a web server and web service. Predicted prophages will help to fill the gaps in the current sparse phage sequence space, which should cover an estimated 100 million species. Systematic and reliable predictions will enable further studies of prophages contribution to the bacteriophage gene pool and to better understand gene shuffling between prophages and phages infecting the same host.
引用
收藏
页码:863 / 865
页数:3
相关论文
共 6 条
[1]  
ALTSCHUL SF, 1997, NUCLEIC ACIDS RES, V25, P3402
[2]   Prophages and bacterial genomics: what have we learned so far? [J].
Casjens, S .
MOLECULAR MICROBIOLOGY, 2003, 49 (02) :277-300
[3]   Phage_Finder:: Automated identification and classification of prophage regions in complete bacterial genome sequences [J].
Fouts, Derrick E. .
NUCLEIC ACIDS RESEARCH, 2006, 34 (20) :5839-5851
[4]   Evolutionary relationships among diverse bacteriophages and prophages: All the world's a phage [J].
Hendrix, RW ;
Smith, MCM ;
Burns, RN ;
Ford, ME ;
Hatfull, GF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2192-2197
[5]   ACLAME: A CLAssification of mobile genetic elements [J].
Leplae, R ;
Hebrant, A ;
Wodak, SJ ;
Toussaint, A .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D45-D49
[6]   Global phage diversity [J].
Rohwer, F .
CELL, 2003, 113 (02) :141-141