Structure-function correlations of snake venom disintegrins

被引：55

作者：

Calvete, JJ ^{[1
]}

机构：

[1] CSIC, Inst Biomed Valencia, E-46010 Valencia, Spain

来源：

CURRENT PHARMACEUTICAL DESIGN | 2005年 / 11卷 / 07期

关键词：

D O I：

10.2174/1381612053381783

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, which selectively block the function of beta(1) and beta(3) integrin receptors. Research on disintegrins is relevant for understanding the biology of viper venom toxins, but also provides information of new structural determinants involved in integrin recognition that may be useful in both, basic and clinical research. The role of the composition, conformation and concerted dynamics of the integrin inhibitory loop and the C-terminal tail in determining the selective inhibition of integrin receptors is discussed.

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页码：829 / 835

页数：7

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