Cross-talk between pRb/E2F and Wnt/β-catenin pathways:: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death

被引：37

作者：

Hughes, TA ^{[1
]}

Brady, HJM ^{[1
]}

机构：

[1] UCL, Inst Child Hlth, Mol Haematol & Canc Biol Unit, Camelia Botnar Labs, London WC1N 1EH, England

来源：

EXPERIMENTAL CELL RESEARCH | 2005年 / 303卷 / 01期

基金：

英国医学研究理事会;

关键词：

axin2; E2F1; Wnt; cell death;

D O I：

10.1016/j.yexcr.2004.09.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pRb/E2F and Wnt/beta-catenin pathways are two of the most frequently deregulated pathways in human cancers. In this study, we show that E2F1 up-regulates the expression of axing. Further, we show that axing can repress Writ signalling leading to reduced cell growth and increased cell death. This represents cross-talk between major pathways involved in the formation of tumours. We use our data to suggest a novel mechanism for tumour suppression. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：32 / 46

页数：15

共 68 条

[1] Stem cells in the skin: waste not, Wnt not
Alonso, L
Fuchs, E
[J]. GENES & DEVELOPMENT, 2003, 17 (10) : 1189 - 1200
[2] Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter
Araki, K
Nakajima, Y
Eto, K
Ikeda, MA
[J]. ONCOGENE, 2003, 22 (48) : 7632 - 7641
[3] Barlund M, 1997, GENE CHROMOSOME CANC, V20, P372, DOI 10.1002/(SICI)1098-2264(199712)20:4<372::AID-GCC8>3.0.CO
[4] 2-Z
[5] Tumorigenesis and the angiogenic switch
Bergers, G
Benjamin, LE
[J]. NATURE REVIEWS CANCER, 2003, 3 (06) : 401 - 410
[6] E2F and Ras Synergize in Transcriptionally Activating p14ARF Expression
Berkovich, Eli
Lamed, Yocheved
Ginsberg, Doron
[J]. CELL CYCLE, 2003, 2 (02) : 127 - 133
[7] TRANSCRIPTION FACTOR E2F IS REQUIRED FOR EFFICIENT EXPRESSION OF THE HAMSTER DIHYDROFOLATE-REDUCTASE GENE INVITRO AND INVIVO
BLAKE, MC
AZIZKHAN, JC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (11) : 4994 - 5002
[8] TCF: Lady justice casting the final verdict on the outcome of Wnt signalling
Brantjes, H
Barker, N
van Es, J
Clevers, H
[J]. BIOLOGICAL CHEMISTRY, 2002, 383 (02) : 255 - 261
[9] Gastrointestinal stem cells
Brittan, M
Wright, NA
[J]. JOURNAL OF PATHOLOGY, 2002, 197 (04) : 492 - 509
[10] Church VL, 2002, INT J DEV BIOL, V46, P927

← 1 2 3 4 5 6 7 →