Mass spectrometric profile of exhaled breath - field study by PTR-MS

被引：146

作者：

Moser, B

Bodrogi, F

Eibl, G

Lechner, M

Rieder, J

Lirk, P

机构：

[1] Leopold Franzens Univ, Dept Anesthesiol & Crit Care Med, A-6020 Innsbruck, Austria

[2] Leopold Franzens Univ, Dept Biostat, A-6020 Innsbruck, Austria

[3] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2005年 / 145卷 / 2-3期

关键词：

compounds; organic; volatile; disease; screening; volatile organic compounds; gas exchange; exhaled air profile; mammals; human; techniques; mass spectrometry; proton transfer reaction;

D O I：

10.1016/j.resp.2004.02.002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recently, increased interest has focused on the diagnostic potential of volatile organic compounds (VOC) exhaled in human breath as this substance group has been conjectured in indoor air quality and disease screening. Proton transfer reaction-mass spectrometry (PTR-MS) has been established as a new tool for a rapid determination of exhaled air profile. However, no investigations have been carried out into the profile of exhaled air as determined by PTR-MS. Therefore, it was the aim of the present study to determine the profile of exhaled breath in a field survey enrolling 344 persons. Analysis was performed using PTR-MS. No significant correlations with age, blood pressure, and body mass index could be observed with any molecular mass. The present study delineates possible reference values for PTR-MS investigations into exhaled air profile. In conclusion, the present study was the first to delineate mass spectrometric characteristics of an average patient sample as possible reference values. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：295 / 300

页数：6

共 19 条

[1] Volatile alkanes and increased concentrations of isoprene in exhaled air during hemodialysis [J].