A very high level of crossreactivity is an essential feature of the T-cell receptor

被引：756

作者：

Mason, D ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, MRC, Cellular Immunol Unit, Oxford OX1 3RE, England

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(98)01299-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is commonly accepted that a high level of antigen specificity is a feature of T-cell activation. However, here, Don Mason argues that a comprehensive response to foreign antigens requires that T cells are widely crossreactive, such that one cell reacts productively with approximately 10(6) different MHC-associated minimal peptide epitopes.

引用

页码：395 / 404

页数：10

共 57 条

[1] T-CELL RECOGNITION OF LYSOZYME - THE BIOCHEMICAL BASIS OF PRESENTATION [J].

ALLEN, PM ;

BABBITT, BP ;

UNANUE, ER .

IMMUNOLOGICAL REVIEWS, 1987, 98 :171-187

[2]

ANDERTON SM, 1994, J IMMUNOL, V152, P3656

[3] How selective is the transporter associated with antigen processing? [J].

Androlewicz, MJ ;

Cresswell, P .

IMMUNITY, 1996, 5 (01) :1-5

[4] PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS [J].

ASHTONRICKARDT, PG ;

VANKAER, L ;

SCHUMACHER, TNM ;

PLOEGH, HL ;

TONEGAWA, S .

CELL, 1993, 73 (05) :1041-1049

[5] REPERTOIRE-DETERMINING ROLE OF PEPTIDE IN THE POSITIVE SELECTION OF CD8+ T-CELLS [J].

ASHTONRICKARDT, PG ;

VANKAER, L ;

SCHUMACHER, TNM ;

PLOEGH, HL ;

TONEGAWA, S .

IMMUNOLOGICAL REVIEWS, 1993, 135 :157-182

[6] RADIATION CHIMAERA, HOST H-2 ANTIGENS DETERMINE IMMUNE RESPONSIVENESS OF DONOR CYTOTOXIC CELLS [J].

BEVAN, MJ .

NATURE, 1977, 269 (5627) :417-418

[7]

BHARDWAJ V, 1993, J IMMUNOL, V151, P5000

[8] Massive expansion of antigen-specific CD8+ T cells during an acute virus infection [J].

Butz, EA ;

Bevan, MJ .

IMMUNITY, 1998, 8 (02) :167-175

[9] PREDOMINANT NATURALLY PROCESSED PEPTIDES BOUND TO HLA-DR1 ARE DERIVED FROM MHC-RELATED MOLECULES AND ARE HETEROGENEOUS IN SIZE [J].

CHICZ, RM ;

URBAN, RG ;

LANE, WS ;

GORGA, JC ;

STERN, LJ ;

VIGNALI, DAA ;

STROMINGER, JL .

NATURE, 1992, 358 (6389) :764-768

[10] T-CELL ANTIGEN RECEPTOR GENES AND T-CELL RECOGNITION [J].

DAVIS, MM ;

BJORKMAN, PJ .

NATURE, 1988, 334 (6181) :395-402

← 1 2 3 4 5 6 →