Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

被引：41

作者：

Scheja, A ^{[1
]}

Åkesson, A

Geborek, P

Wildt, M

Wollheim, CB

Wollheim, FA

Vischer, UM

机构：

[1] Univ Lund Hosp, Dept Rheumatol, S-22185 Lund, Sweden

[2] Ctr Med Univ Geneva, Dept Med Interne, Div Biochim Clin, Geneva, Switzerland

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 03期

关键词：

systemic sclerosis; von Willebrand factor; von Willebrand factor propeptide;

D O I：

10.1186/ar295

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

引用

页码：178 / U1

页数：6

共 32 条

[1]

AKESSON A, 1989, BRIT J RHEUMATOL, V28, P281

[2] PRELIMINARY CRITERIA FOR THE CLASSIFICATION OF SYSTEMIC-SCLEROSIS (SCLERODERMA) [J].