Increased serum cystatin C is associated with increased mortality in elderly men

被引：24

作者：

Larsson, A ^{[1
]}

Helmersson, J

Hansson, LO

Basu, S

机构：

[1] Univ Uppsala Hosp, Dept Med Sci, Sect Clin Chem, SE-75185 Uppsala, Sweden

[2] Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci, Sect Geriatr, SE-75185 Uppsala, Sweden

[3] Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci, Sect Clin Nutr Res, SE-75185 Uppsala, Sweden

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2005年 / 65卷 / 04期

关键词：

cystatin C; glomerular filtration rate; human; kidney; mortality;

D O I：

10.1080/00365510510013839

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Renal dysfunction measured by serum creatinine is associated with increased cardiovascular morbidity and mortality. Plasma cystatin C has been shown in several studies to be superior to plasma creatinine for the estimation of glomerular filtration rate (GFR). The aim of the present study was to investigate the relationship between cystatin C and mortality in elderly men. Serum cystatin C was analyzed by nephelometry in a group of 77-year-old men (n=792) and correlated cystatin C levels with mortality during a follow-up period of 1-4 years. The cystatin C values were significantly correlated with overall mortality (p=0.013). Mortality was three times higher in the highest cystatin C quintile in relation to the lowest quintile.

引用

页码：301 / 305

页数：5

共 20 条

[1] CONTRAST-MEDIA AS MARKERS FOR GLOMERULAR-FILTRATION - A PHARMACOKINETIC COMPARISON OF 4 AGENTS [J].

BACK, SE ;

KRUTZEN, E ;

NILSSONEHLE, P .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1988, 48 (03) :247-253

[2] Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men [J].

Byberg, L ;

Siegbahn, A ;

Berglund, L ;

McKeigue, P ;

Reneland, R ;

Lithell, H .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (02) :258-264

[3] Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency [J].

Culleton, BF ;

Larson, MG ;

Wilson, PWF ;

Evans, JC ;

Parfrey, PS ;

Levy, D .

KIDNEY INTERNATIONAL, 1999, 56 (06) :2214-2219

[4] Prevalence and correlates of elevated serum creatinine levels - The Framingham heart study [J].

Culleton, BF ;

Larson, MG ;

Evans, JC ;

Wilson, PWF ;

Barrett, BJ ;

Parfrey, PS ;

Levy, D .

ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (15) :1785-1790

[5] MICROALBUMINURIA AS PREDICTOR OF INCREASED MORTALITY IN ELDERLY PEOPLE [J].

DAMSGAARD, EM ;

FROLAND, A ;

JORGENSEN, OD ;

MOGENSEN, CE .

BRITISH MEDICAL JOURNAL, 1990, 300 (6720) :297-300

[6] Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis [J].

Dharnidharka, VR ;

Kwon, C ;

Stevens, G .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 40 (02) :221-226

[7] Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals [J].

Fried, LF ;

Shlipak, MG ;

Crump, C ;

Bleyer, AJ ;

Gottdiener, JS ;

Kronmal, RA ;

Kuller, LH ;

Newman, AB .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (08) :1364-1372

[8]

GASPARI F, 1997, KIDNEY INT S, V63, P151

[9] Cystatin C - Properties and use as diagnostic marker [J].

Grubb, AO .

ADVANCES IN CLINICAL CHEMISTRY, VOL 35, 2001, 35 :63-99

[10] Diabetes, hemoglobin A1c, cholesterol, and the risk of moderate chronic renal insufficiency in an ambulatory population [J].

Hsu, CY ;

Bates, DW ;

Kuperman, GJ ;

Curhan, GC .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2000, 36 (02) :272-281

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