DNA-cation interactions: the major and minor grooves are flexible ionophores

被引：175

作者：

Hud, NV ^{[1
]}

Polak, M

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[2] Natl Inst Chem, Slovenian NMR Ctr, Ljubljana, Slovenia

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(00)00205-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several crystallographic, solution-state and theoretical studies carried out this past year provide new support for the sequence-specific nature of monovalent and divalent cation coordination within the DNA major and minor grooves. Correlations observed between groove width and cation coordination indicate that the grooves are flexible and respond to cation binding.

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页码：293 / 301

页数：9

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