Double vision Pigment genes do more than just color

被引：1

作者：

Ambegaokar, Surendra S. ^{[1
]}

Jackson, George R. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Texas Med Branch, Mitchell Ctr Neurodegenerat Diseases, Dept Neurol, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, Dept Neurosci, Galveston, TX USA

[3] Univ Texas Med Branch, Dept Cell Biol, Galveston, TX USA

[4] Univ Texas Med Branch, Dept Biochem, Galveston, TX USA

[5] Univ Texas Med Branch, Dept Mol Biol, Galveston, TX USA

来源：

FLY | 2011年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

white; brown; rosy; tau; eye; autophagy; S6K; WILD-TYPE; TAU; DROSOPHILA; PROTEIN; WHITE; NEURODEGENERATION; DEGENERATION; AGGREGATION; AUTOPHAGY; BINDING;

D O I：

10.4161/fly.5.3.15142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of P element collections led to the discovery of unanticipated effects from common genetic background mutants white, brown and rosy in our previously reported model of tauopathy that expresses full-length human tau in the fly eye, in which mutant rosy suppresses mutant white and brown worsening of tau-induced toxicity.(1) Here we discuss further possible effects of mini-white and evidence for autophagy as a mediator of white enhancement of tau toxicity.

引用

收藏

页码：206 / 209

页数：4

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