Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation

被引：32

作者：

Chu, John Man Tak ^{[2
]}

Xiong, Wei ^{[1
,2
]}

Linghu, Ke Gang ^{[1
]}

Liu, Yan ^{[2
]}

Zhang, Yan ^{[2
]}

Zhao, Guan Ding ^{[1
]}

Irwin, Michael G. ^{[2
]}

Wong, Gordon Tin Chun ^{[2
]}

Yu, Hua ^{[1
,3
,4
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[2] Univ Hong Kong, LKS Fac Med, Dept Anaesthesiol, Pokfulam, Hong Kong 999077, Peoples R China

[3] HKBU Shenzhen Res Ctr, Shenzhen 518000, Guangdong, Peoples R China

[4] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong 999077, Peoples R China

来源：

EXPERIMENTAL NEUROBIOLOGY | 2018年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Surgery; Cognitive dysfunction; inflammation; Tau; NF-KAPPA-B; ASTROCYTES; RESPONSES; MEMORY; BRAIN;

D O I：

10.5607/en.2018.27.6.564

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

A proportion of patients experience acute or even prolonged cognitive impairment after surgery, a condition known as postoperative cognitive dysfunction (POCD). It is characterized by impairment in different cognitive domains and neuroin-flammation has been implicated as one of the inciting factors as strategies targeting inflammation tend to improve cognitive performance. Sieges&Ala Orientals L. (S Orientals) is a common Chinese medicinal herb used for managing chronic inflammatory diseases. We investigated if pretreatment with S Orientals before surgery confers any neuro-protective effects in postoperative animals in terms of reducing inflammation and mitigating cognitive impairment. Three-month-old male C57BL/6N mice were fed different doses of S. Orientals extract for 14 days before they underwent a laparotomy After cognitive testing they were sacrificed on postoperative day (POD) 3. Our results showed that animals with extract pretreatment demonstrated memory improvement in a dose-dependent manner compared with control Further, evidence for the attenuation of systemic and neuroin-flammation was found in the pretreated animals, along with the inhibition of inflammatory pathways and significantly reduced tau phosphorylation in the hippocampus. Taken together, these results demonstrated a neuro-protective effect of S. Orientals in postoperative animals, indicating a therapeutic potential of S. Orientals in minimizing POCD and the possibility of utilizing this traditional Chinese medicine perioperatively.

引用

页码：564 / 573

页数：10

共 32 条

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When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease [J].