Deeper into the genome

被引：20

作者：

Gibbs, R ^{[1
]}

机构：

[1] Baylor Coll Med, Houston, TX 77030 USA

来源：

NATURE | 2005年 / 437卷 / 7063期

关键词：

D O I：

10.1038/4371233a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The next large-scale human genome project after HapMap should catalogue inherited variation in the general population that directly affects gene function, argues Richard Gibbs. ©2005 Nature Publishing Group.

引用

页码：1233 / 1234

页数：2

共 8 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2] Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease [J].

Botstein, D ;

Risch, N .

NATURE GENETICS, 2003, 33 (Suppl 3) :228-237

[3] Low LDL cholesterol in African Americans resulting from frequent nonsense mutations in PCSK9 [J].

Cohen, J ;

Pertsemlidis, A ;

Kotowski, IK ;

Graham, R ;

Garcia, CK ;

Hobbs, HH .

NATURE GENETICS, 2005, 37 (03) :328-328

[4] MULTIPLEX DNA DELETION DETECTION AND EXON SEQUENCING OF THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE GENE IN LESCH-NYHAN FAMILIES [J].

GIBBS, RA ;

NGUYEN, PN ;

EDWARDS, A ;

CIVITELLO, AB ;

CASKEY, CT .

GENOMICS, 1990, 7 (02) :235-244

[5] ImageNet Classification with Deep Convolutional Neural Networks [J].

Krizhevsky, Alex ;

Sutskever, Ilya ;

Hinton, Geoffrey E. .

COMMUNICATIONS OF THE ACM, 2017, 60 (06) :84-90

[6] Genomic research and human subject privacy [J].

Lin, Z ;

Owen, AB ;

Altman, RB .

SCIENCE, 2004, 305 (5681) :183-183

[7] The allelic architecture of human disease genes: common disease - common variant ... or not? [J].

Pritchard, JK ;

Cox, NJ .

HUMAN MOLECULAR GENETICS, 2002, 11 (20) :2417-2423

[8] On the allelic spectrum of human disease [J].

Reich, DE ;

Lander, ES .

TRENDS IN GENETICS, 2001, 17 (09) :502-510

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