Genetic targeting strategies for adenovirus

被引:56
作者
Noureddini, Sam C. [5 ]
Curiel, David T. [1 ,2 ,3 ,4 ]
机构
[1] Univ Alabama, Gene Therapy Ctr, Birmingham, AL 35294 USA
[2] Univ Alabama, Dept Med, Div Human Gene Therapy, Birmingham, AL 35294 USA
[3] Univ Alabama, Dept Pathol, Div Human Gene Therapy, Birmingham, AL 35294 USA
[4] Univ Alabama, Dept Surg, Div Human Gene Therapy, Birmingham, AL 35294 USA
[5] VectorLogics Inc, Birmingham, AL 35294 USA
关键词
adenovirus; gene therapy; target cell; gene transfer; review;
D O I
10.1021/mp050045c
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Adenovirus serotype 5 (Ad5) continues to be regarded as a gene delivery vehicle of high utility for a variety of clinical applications. However, targeting of the virus to alternate, non-native receptors has become a mandate for many gene therapy approaches, as inefficient viral transduction of target tissues has proven detrimental to the utility of Ad5. Thus, various targeting strategies have been endeavored to the end of highly specific cellular transduction, including that of genetic manipulation of the viral capsid. Modification of the tropism-determining fiber protein and other capsid locales has allowed vectorologists to develop vectors that are highly superior to the first-generation adenoviruses employed for gene therapy. Herein, the various genetic targeting strategies for Ad5 are reviewed, and the various schemas in which targeted transduction has been achieved with tropism-modified vectors are outlined.
引用
收藏
页码:341 / 347
页数:7
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