Selective serotonin reuptake inhibitors may enhance responses to noxious stimulation

被引:13
作者
Dirksen, R
Van Luijtelaar, ELJM
Van Rijn, CM
机构
[1] Univ Nijmegen, Inst Anesthesiol, NICI Expt Anesthesiol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen, NICI, Dept Psychol, NL-6500 HB Nijmegen, Netherlands
关键词
nociception; fluoxetine; fluvoxamine; noxious-induced withdrawal reflex;
D O I
10.1016/S0091-3057(98)00030-6
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The acute effects of various doses of two selective serotonin reuptake inhibitors (fluoxetine and fluvoxamine) on thermal and electrical stimulation-induced pain were investigated in drug-naive Wistar rats. The hot-plate and the tail-flick test and the noxious-induced withdrawal test were used. The two drugs had no effects on heat-induced pain behavior. However, the two compounds enhanced the motor responses induced by noxious electrical stimulation. These data contrast to what is generally found for tricyclic antidepressants and suggest a modality specific pain system. Cardiac and blood pressure were also found to change, but these changes were not correlated to changes in nociception. Taken together, the data suggest that the acutely administered selective serotonin reuptake inhibitors may exacerbate an acute type of pain. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:719 / 725
页数:7
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