Diagnostic value of CEA, CA 15-3, CA 19-9, CYFRA 21-1, NSE and TSA assay in pleural effusions

被引:95
作者
Alatas, F [1 ]
Alatas, Ö
Metintas, M
Çolak, Ö
Harmanci, E
Demir, S
机构
[1] Osmangazi Univ, Sch Med, Dept Chest Dis, TR-26470 Eskisehir, Turkey
[2] Osmangazi Univ, Sch Med, Dept Biochem, Eskisehir, Turkey
关键词
CEA; CA; 15-3; 19-9; CYFRA; 21-1; NSE; TSA; tumor markers; pleural effusion;
D O I
10.1016/S0169-5002(00)00153-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study was to evaluate the individual and combined diagnostic utility of six tumor markers in patients with pleural effusion. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA 15-3), carbohydrate antigen 19-9 (CA 19-9), cytokeratin Fragment 19 (CYFRA 21-1), neuron-specific enolase (NSE) and total sialic acid (TSA) were assayed in 74 patients with pleural effusions (44 malignant and 30 benign). All tumor markers except TSA and NSE were increased in both serum and pleural fluid of patients with malignant diseases. Using the cut-off values 3 ng/ml. 14 U/ml, 5 U/ml, 8 ng/ml and 70 mg/dl for pleural fluid CEA, CA 15-3, CA 19-9, CYFRA 21-1 and TSA, respectively, the sensitivity (%) and specificity (%) Of these tumor markers were as follows: CEA, 52/77, CA 15-3; 80/93, CA 19-9; 36/83, CYFRA 21-1; 91/90, TSA, 80/67, for differentiating malignant effusions from benign. When CA 15-3 and CYFRA 21-1 combined, the sensitivity and specificity were increased (100 and 83%, respectively). Classifying the malignant effusions as bronchial carcinoma and malignant pleural mesothelioma, CEA was shown to have the highest sensitivity and specificity (88 and 90%, respectively) while the combination of CEA with other tumor markers increased sensitivity but decreased specificity. According to our results, tumor markers are not suitable for the differential diagnosis of malignancy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
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页码:9 / 16
页数:8
相关论文
共 32 条
[1]  
Berzinec P, 1996, NEOPLASMA, V43, P159
[2]   SERUM SIALIC ACID LEVELS IN HEALTH AND DISEASE [J].
CARTER, A ;
MARTIN, NH .
JOURNAL OF CLINICAL PATHOLOGY, 1962, 15 (01) :69-&
[3]  
DEKKER A, 1978, AM J CLIN PATHOL, V70, P855
[4]   THE ROLE OF CONCURRENT DETERMINATIONS OF PLEURAL FLUID AND TISSUE CARCINOEMBRYONIC ANTIGEN IN THE DISTINCTION OF MALIGNANT MESOTHELIOMA FROM METASTATIC PLEURAL MALIGNANCIES [J].
FARAVELLI, B ;
NOSENZO, M ;
RAZZETTI, A ;
BARONE, D ;
DAMORE, E ;
BANDELLONI, R ;
GAMBINI, C ;
BETTA, PG ;
DONNA, A .
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1985, 21 (09) :1083-1087
[5]  
GANDHI A K, 1989, Indian Journal of Medical Research Section B, V90, P22
[6]   Comparison of cytokeratin fragment 19 (CYFRA 21-1), tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) as tumour markers in bronchogenic carcinoma [J].
Huang, MS ;
Jong, SB ;
Tsai, MS ;
Lin, MS ;
Chong, IW ;
Lin, HC ;
Hwang, JJ .
RESPIRATORY MEDICINE, 1997, 91 (03) :135-142
[7]   DIAGNOSTIC-VALUE OF SIALIC-ACID IN MALIGNANT PLEURAL EFFUSIONS [J].
IMECIK, O ;
OZER, F .
CHEST, 1992, 102 (06) :1819-1822
[8]  
JARVISALO J, 1993, CANCER-AM CANCER SOC, V71, P1982, DOI 10.1002/1097-0142(19930315)71:6<1982::AID-CNCR2820710610>3.0.CO
[9]  
2-G
[10]  
KAKARI S, 1991, ANTICANCER RES, V11, P2107