Real-time PCR as a versatile tool for investigating the susceptibility of human herpesvirus 6 to antiviral agents

被引：19

作者：

Macé, M

Manichanh, C

Bonnafous, P

Précigout, S

Boutolleau, D

Gautheret-Dejean, A

Agut, H

机构：

[1] Grp Hosp Pitie Salpetriere, CERVI, Virol Lab, UPRES EA2387, F-75013 Paris, France

[2] Fac Sci Pharmaceut & Biol Paris, Microbiol Lab, F-75006 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 09期

关键词：

D O I：

10.1128/AAC.47.9.3021-3024.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A quantitative real-time PCR assay was developed for the determination of antiviral drug susceptibility and growth kinetics of human herpesvirus 6. The susceptibility and fitness of a sensitive strain, HST, and its ganciclovir-resistant derivative, GCVR1, were then characterized, leading us to conclude that the mutations of this latter virus did not alter its fitness significantly.

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页码：3021 / 3024

页数：4

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