PrrC, a Sco homologue from Rhodobacter sphaeroides, possesses thiol-disulfide oxidoreductase activity

被引：26

作者：

Badrick, Alison C. ^{[1
]}

Hamilton, Amanda J. ^{[1
]}

Bernhardt, Paul V. ^{[1
]}

Jones, Christopher E. ^{[1
]}

Kappler, Ulrike ^{[1
]}

Jennings, Michael P. ^{[1
]}

McEwan, Alastair G. ^{[1
]}

机构：

[1] Univ Queensland, Sch Mol & Microbial Sci, Ctr Met Biol, Brisbane, Qld 4072, Australia

来源：

FEBS LETTERS | 2007年 / 581卷 / 24期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Sco; copper; cytochrome c oxidase; thioredoxin; insulin;

D O I：

10.1016/j.febslet.2007.08.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PrrC is a Sco homologue in Rhodobacter sphaeroides that is associated with PrrBA, a two-component signal transduction system that induces photosynthesis gene expression in response to a decrease in oxygen tension. Although Sco proteins have been shown to bind copper the observation that they are structurally-related to thioredoxins suggested that they might possess thiol-disulfide oxidoreductase activity. Our results show that PrrC reduces Cu2+ to Cu+ and possesses disulfide reductase activity. These results indicate that some bacterial Sco proteins may have biochemical properties that are distinct from those of mitochondrial Sco proteins. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4663 / 4667

页数：5

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