HtrA2 and Parkinson's disease: think PiNK?

被引：19

作者：

Alnemri, Emad S. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USA

来源：

NATURE CELL BIOLOGY | 2007年 / 9卷 / 11期

关键词：

D O I：

10.1038/ncb1107-1227

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial dysfunction is primarily responsible for neurodegeneration in Parkinson's disease. The Parkinson's-disease-associated kinase PINK1 has been identified as an important regulator of the activity of the mitochondria-associated stress-protective protease HtrA2.

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页码：1227 / 1229

页数：5

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