Cultivating Healthy Growth and Nutrition through the Gut Microbiota

被引:148
作者
Subramanian, Sathish [1 ,2 ]
Blanton, Laura V. [1 ,2 ]
Frese, Steven A. [3 ,4 ]
Charbonneau, Mark [1 ,2 ]
Mills, David A. [3 ,4 ]
Gordon, Jeffrey I. [1 ,2 ]
机构
[1] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA
[2] Washington Univ, Sch Med, Ctr Gut Microbiome & Nutr Res, St Louis, MO 63108 USA
[3] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA
[4] Univ Calif Davis, Dept Viticulture & Enol, Davis, CA 95616 USA
基金
比尔及梅琳达.盖茨基金会;
关键词
HUMAN-MILK OLIGOSACCHARIDES; SECRETORY IMMUNOGLOBULIN-A; MAL-ED COHORT; INTESTINAL INFLAMMATION; BOVINE-MILK; BREAST-MILK; N-GLYCANS; BIFIDOBACTERIA; INFANTS; PRETERM;
D O I
10.1016/j.cell.2015.03.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Microbiota assembly is perturbed in children with undernutrition, resulting in persistent microbiota immaturity that is not rescued by current nutritional interventions. Evidence is accumulating that this immaturity is causally related to the pathogenesis of undernutrition and its lingering sequelae. Preclinical models in which human gut communities are replicated in gnotobiotic mice have provided an opportunity to identify and predict the effects of different dietary ingredients on microbiota structure, expressed functions, and host biology. This capacity sets the stage for proof-of-concept tests designed to deliberately shape the developmental trajectory and configurations of microbiota in children representing different geographies, cultural traditions, and states of health. Developing these capabilities for microbial stewardship is timely given the global health burden of childhood undernutrition, the effects of changing eating practices brought about by globalization, and the realization that affordable nutritious foods need to be developed to enhance our capacity to cultivate healthier microbiota in populations at risk for poor nutrition.
引用
收藏
页码:36 / 48
页数:13
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