Human T cells constitutively express IL-15 that promotes ex vivo T cell homeostatic proliferation through autocrine/juxtacrine loops

被引：25

作者：

Miranda-Carús, ME ^{[1
]}

Benito-Miguel, M ^{[1
]}

Llamas, MA ^{[1
]}

Balsa, A ^{[1
]}

Martín-Mola, E ^{[1
]}

机构：

[1] Hosp Univ La Paz, Dept Rheumatol, Madrid 28046, Spain

来源：

JOURNAL OF IMMUNOLOGY | 2005年 / 175卷 / 06期

关键词：

D O I：

10.4049/jimmunol.175.6.3656

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Homeostatic proliferation of T cells in vivo is responsible for the maintainance of the T cell pool, and IL-15 is a pivotal cytokine implicated in this process. Known cell sources providing physiologically active IL-15 are monocytes/macrophages, dendritic cells, and stromal cells. T lymphocyte expression of functionally active IL-15 and its possible role in T cell biology have not been investigated. In this study, we demonstrate that human T cells constitutively express IL-15 that acts through autocrine/juxtacrine loops to promote ex vivo homeostatic T cell proliferation.

引用

页码：3656 / 3662

页数：7

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