Chronic Inflammatory Diseases and Cardiovascular Risk: A Systematic Review

被引:131
作者
Roifman, Idan [1 ]
Beck, Paul L. [2 ]
Anderson, Todd J. [3 ]
Eisenberg, Mark J. [3 ,4 ,5 ]
Genest, Jacques [1 ]
机构
[1] McGill Univ, Ctr Hlth, Cardiovasc Res Labs, Montreal, PQ H3A 1A1, Canada
[2] Univ Calgary, Dept Med, Div Gastroenterol, Calgary, AB, Canada
[3] Univ Calgary, Libin Cardiovasc Inst, Calgary, AB, Canada
[4] McGill Univ, Jewish Gen Hosp, Div Cardiol, Montreal, PQ H3T 1E2, Canada
[5] McGill Univ, Jewish Gen Hosp, Div Clin Epidemiol, Montreal, PQ H3T 1E2, Canada
关键词
C-REACTIVE-PROTEIN; CORONARY-ARTERY-DISEASE; RHEUMATOID-ARTHRITIS; LUPUS-ERYTHEMATOSUS; MYOCARDIAL-INFARCTION; ENDOTHELIAL FUNCTION; BOWEL-DISEASE; HEART-DISEASE; EARLY ATHEROSCLEROSIS; VASCULAR-DISEASE;
D O I
10.1016/j.cjca.2010.12.040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite recent advancements in the treatment of coronary artery disease (CAD), it remains the number one cause of death in the world. While traditional risk factors partially account for the development of CAD, other novel risk factors have recently been implicated. Specifically, chronic inflammation has been postulated to play a role in the development and propagation of this disease. The purpose of this systematic review is to examine the available evidence to determine if patients with chronic inflammatory diseases have higher rates of cardiovascular disease. A MEDLINE search was conducted for articles published between 1980-2009. We focused on studies that assessed hard cardiovascular endpoints in subjects with chronic inflammatory conditions such as systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, polymyositis/dermatomyositis, and inflammatory bowel disease. Although largely based on small studies, our review indicates that patients with chronic inflammatory conditions are likely at elevated risk for the development of CAD. Further research consisting of prospective cohort studies is needed to better quantify this risk.
引用
收藏
页码:174 / 182
页数:9
相关论文
共 51 条
[1]   Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death [J].
Albert, CM ;
Ma, J ;
Rifai, N ;
Stampfer, MJ ;
Ridker, PM .
CIRCULATION, 2002, 105 (22) :2595-2599
[2]   Lipoprotein-associated phospholipase A2:: An independent predictor of coronary artery disease events in primary and secondary prevention [J].
Anderson, Jeffrey L. .
AMERICAN JOURNAL OF CARDIOLOGY, 2008, 101 (12A) :23F-33F
[3]   The incidence of arterial thromboembolic diseases in inflammatory bowel disease: A population-based study [J].
Bernstein, Charles N. ;
Wajda, Andre ;
Blanchard, James F. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2008, 6 (01) :41-45
[4]   C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-analyses for the US Preventive Services Task Force [J].
Buckley, David I. ;
Fu, Rongwei ;
Freeman, Michele ;
Rogers, Kevin ;
Helfand, Mark .
ANNALS OF INTERNAL MEDICINE, 2009, 151 (07) :483-W161
[5]  
del Rincón I, 2001, ARTHRITIS RHEUM-US, V44, P2737, DOI 10.1002/1529-0131(200112)44:12<2737::AID-ART460>3.0.CO
[6]  
2-#
[7]   Newer therapeutic approaches for systemic lupus erythematosus: Immunosuppressive agents [J].
Dooley, MA ;
Ginzler, EM .
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2006, 32 (01) :91-+
[8]   Inflammatory bowel disease is not a risk factor for cardiovascular disease mortality: Results from a systematic review and meta-analysis [J].
Dorn, Spencer D. ;
Sandler, Robert S. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (03) :662-667
[9]  
Esdaile JM, 2001, ARTHRITIS RHEUM, V44, P2331, DOI 10.1002/1529-0131(200110)44:10<2331::AID-ART395>3.0.CO
[10]  
2-I