Unruptured intracranial aneurysms -: Risk of rupture and risks of surgical intervention

被引：1292

作者：

Wiebers, D ^{[1
]}

Whisnant, J ^{[1
]}

Forbes, G ^{[1
]}

Meissner, I ^{[1
]}

Brown, R ^{[1
]}

Piepgras, D ^{[1
]}

Huston, J ^{[1
]}

Nichols, D ^{[1
]}

O'Fallon, W ^{[1
]}

Peacock, J ^{[1
]}

Jaeger, L ^{[1
]}

Kassell, N ^{[1
]}

Kongable-Beckman, G ^{[1
]}

Torner, J ^{[1
]}

Rajput, M ^{[1
]}

Drake, C ^{[1
]}

Kurtzke, J ^{[1
]}

Marler, J ^{[1
]}

Walker, M ^{[1
]}

Meyer, F ^{[1
]}

Atkinson, J ^{[1
]}

Marsh, W ^{[1
]}

Thielen, K ^{[1
]}

Ferguson, G ^{[1
]}

Barr, H ^{[1
]}

Lownie, S ^{[1
]}

Hachinski, V ^{[1
]}

Fox, A ^{[1
]}

Sahjpaul, R ^{[1
]}

Parrent, A ^{[1
]}

Mayer, C ^{[1
]}

Lindsay, K ^{[1
]}

Teasdale, E ^{[1
]}

Bone, I ^{[1
]}

Fatukasi, J ^{[1
]}

Lindsay, M ^{[1
]}

Cail, W ^{[1
]}

Sagher, O ^{[1
]}

Davis, M ^{[1
]}

Sengupta, R ^{[1
]}

Bates, D ^{[1
]}

Gholkar, A ^{[1
]}

Murdy, J ^{[1
]}

Wilson, S ^{[1
]}

Praharaj, S ^{[1
]}

Partridge, G ^{[1
]}

Reynolds, C ^{[1
]}

Hind, N ^{[1
]}

Ogilvy, C ^{[1
]}

Crowell, R ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, ISUIA Coordinating Ctr, Rochester, MN 55905 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1998年 / 339卷 / 24期

关键词：

D O I：

10.1056/nejm199812103392401

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The management of unruptured intracranial aneurysms requires knowledge of the natural history of these lesions and the risks of repairing them. Methods A total of 2621 patients at 53 participating centers in the United States, Canada, and Europe were enrolled in the study, which had retrospective and prospective components. In the retrospective component, we assessed the natural history of unruptured intracranial aneurysms in 1449 patients with 1937 such aneurysms; 727 of the patients had no history of subarachnoid hemorrhage from a different aneurysm (group 1), and 722 had a history of subarachnoid hemorrhage from a different aneurysm that had been repaired successfully (group 2). In the prospective component, we assessed treatment-related morbidity and mortality in 1172 patients with newly diagnosed unruptured intracranial aneurysms. Results In group 1, the cumulative rate of rupture of aneurysms that were less than 10 mm in diameter at diagnosis was less than 0.05 percent per year, and in group 2, the rate was approximately 11 times as high (0.5 percent per year). The rupture rate of aneurysms that were 10 mm or more in diameter was less than 1 percent per year in both groups, but in group 1, the rate was 6 percent the first year for giant aneurysms (greater than or equal to 25 mm in diameter). The size and location of the aneurysm were independent predictors of rupture. The overall rate of surgery-related morbidity and mortality was 17.5 percent in group 1 and 13.6 percent in group 2 at 30 days and was 15.7 percent and 13.1 percent, respectively, at 1 year. Age independently predicted surgical outcome. Conclusions The likelihood of rupture of unruptured intracranial aneurysms that were less than 10 mm in diameter was exceedingly low among patients in group 1 and was substantially higher among those in group 2. The risk of morbidity and mortality related to surgery greatly exceeded the 7.5-year risk of rupture among patients in group 1 with unruptured intracranial aneurysms smaller than 10 mm in diameter. (N Engl J Med 1998;339:1725-33.) (C) 1998, Massachusetts Medical Society.

引用

页码：1725 / 1733

页数：9

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