Structural biology - The xyz of ABC transporters

被引:66
作者
Higgins, CF [1 ]
Linton, KJ [1 ]
机构
[1] Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England
关键词
D O I
10.1126/science.1065588
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1782 / 1784
页数:3
相关论文
共 10 条
[1]   Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein [J].
Blott, EJ ;
Higgins, CF ;
Linton, KJ .
EMBO JOURNAL, 1999, 18 (23) :6800-6808
[2]   Multidrug resistance in Lactococcus lactis: Evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane [J].
Bolhuis, H ;
vanVeen, HW ;
Molenaar, D ;
Poolman, B ;
Driessen, AJM ;
Konings, WN .
EMBO JOURNAL, 1996, 15 (16) :4239-4245
[3]   RETRACTED: Structure of MsbA from E-coli:: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters (Retracted Article. See vol 314, pg 1875, 2006) [J].
Chang, G ;
Roth, CB .
SCIENCE, 2001, 293 (5536) :1793-1800
[4]   IS THE MULTIDRUG TRANSPORTER A FLIPPASE [J].
HIGGINS, CF ;
GOTTESMAN, MM .
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (01) :18-21
[5]   A FAMILY OF RELATED ATP-BINDING SUBUNITS COUPLED TO MANY DISTINCT BIOLOGICAL PROCESSES IN BACTERIA [J].
HIGGINS, CF ;
HILES, ID ;
SALMOND, GPC ;
GILL, DR ;
DOWNIE, JA ;
EVANS, IJ ;
HOLLAND, IB ;
GRAY, L ;
BUCKEL, SD ;
BELL, AW ;
HERMODSON, MA .
NATURE, 1986, 323 (6087) :448-450
[6]   Crystal structure of the ATP-binding subunit of an ABC transporter [J].
Hung, LW ;
Wang, IXY ;
Nikaido, K ;
Liu, PQ ;
Ames, GFL ;
Kim, SH .
NATURE, 1998, 396 (6712) :703-707
[7]   Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates [J].
Loo, TW ;
Clarke, DM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) :27482-27487
[8]  
ROSENBERG M, IN PRESS EMBO J
[9]   The structure of the multidrug resistance protein 1 (MRP1/ABCC1) - Crystallization and single-particle analysis [J].
Rosenberg, MF ;
Mao, QC ;
Holzenburg, A ;
Ford, RC ;
Deeley, RG ;
Cole, SPC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) :16076-16082
[10]  
Rosenberg MF, 1997, J BIOL CHEM, V272, P10685