Senescence in chronic liver disease: Is the future in aging?

被引：137

作者：

Arayinthan, Aloysious D. ^{[1
,4
,5
]}

Alexander, Graeme J. M. ^{[2
,3
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON, Canada

[2] Royal Free Trust, UCL Inst Liver & Digest Hlth, London, England

[3] Univ Cambridge, Dept Med, Cambridge, England

[4] Univ Nottingham, Nottingham Digest Dis Biomed Res Unit, NIHR, Nottingham, England

[5] Nottingham Univ Hosp NHS Trust, Nottingham, England

来源：

JOURNAL OF HEPATOLOGY | 2016年 / 65卷 / 04期

关键词：

Cellular senescence; Hepatocyte; senescence; Chronic liver disease; Liver fibrosis; CHRONIC HEPATITIS-C; SMALL BILE-DUCTS; CELLULAR SENESCENCE; HEPATOCYTE SENESCENCE; REPLICATIVE SENESCENCE; TRANSPLANT RECIPIENTS; SECRETORY PHENOTYPE; TELOMERE LENGTH; NUCLEAR AREAS; DNA-DAMAGE;

D O I：

10.1016/j.jhep.2016.05.030

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Cellular senescence is a fundamental, complex mechanism with an important protective role present from embryogenesis to late life across all species. It limits the proliferative potential of damaged cells thus protecting against malignant change, but at the expense of substantial alterations to the microenvironment and tissue homeostasis, driving inflammation, fibrosis and paradoxically, malignant disease if the process is sustained. Cellular senescence has attracted considerable recent interest with recognition of pathways linking aging, malignancy and insulin resistance and the current focus on therapeutic interventions to extend health-span. There are major implications for hepatology in the field of fibrosis and cancer, where cellular senescence of hepatocytes, cholangiocytes, stellate cells and immune cells has been implicated in chronic liver disease progression. This review focuses on cellular senescence in chronic liver disease and explores therapeutic opportunities. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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收藏

页码：825 / 834

页数：10

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