Regioselective synthesis of polysubstituted pyrazoles and isoxazoles

被引：183

作者：

Katritzky, AR ^{[1
]}

Wang, MY ^{[1
]}

Zhang, SM ^{[1
]}

Vonkov, AVV ^{[1
]}

Steel, PJ ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 20期

关键词：

D O I：

10.1021/jo0101407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective synthesis has been developed for the preparation of unsymmetrical 1,3,5-triaryl-4-alkylpyrazolines and -pyrazoles by treatment of alpha -benzotriazolyl-alpha,beta -unsaturated ketones with monosubstituted hydrazines followed by alkylation at the 4-position of the pyrazoline ring. Reaction of alpha -benzotriazolyl-alpha,beta -unsaturated ketones with hydroxylamine gives 3,5-disubstituted isoxazoles regioselectively.

引用

页码：6787 / 6791

页数：5

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