Polymorphisms of the BRCA2 and RAD51 genes in breast cancer

被引：47

作者：

Sliwinski, T

Krupa, R

Majsterek, I

Rykala, J

Kolacinska, A

Morawiec, Z

Drzewoski, J

Zadrozny, M

Blasiak, J

机构：

[1] Univ Lodz, Dept Mol Genet, PL-90237 Lodz, Poland

[2] N Copernicus Hosp, Lodz, Poland

[3] Med Univ Lodz, Dept Clin Pharmacol, Lodz, Poland

[4] Polish Mothers Mem Hosp, Lodz, Poland

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2005年 / 94卷 / 02期

关键词：

BRCA2; breast cancer; DNA repair; gene polymorphism; RAD51;

D O I：

10.1007/s10549-005-0672-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.

引用

收藏

页码：105 / 109

页数：5

相关论文

共 16 条

[1]

Blasiak J, 2003, ACTA BIOCHIM POL, V50, P249

[2] Genetic polymorphisms in DNA repair genes and risk of lung cancer [J].

Butkiewicz, D ;

Rusin, M ;

Enewold, L ;

Shields, PG ;

Chorazy, M ;

Harris, CC .

CARCINOGENESIS, 2001, 22 (04) :593-597

[3] Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G2/M checkpoint control [J].

Chen, CF ;

Chen, PL ;

Zhong, Q ;

Sharp, ZD ;

Lee, WH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :32931-32935

[4] Role of BRCA2 in control of the RAD51 recombination and DNA repair protein [J].

Davies, AA ;

Masson, JY ;

Mcllwraith, MJ ;

Stasiak, AZ ;

Stasiak, A ;

Venkitaraman, AR ;

West, SC .

MOLECULAR CELL, 2001, 7 (02) :273-282

[5]

Goode EL, 2002, CANCER EPIDEM BIOMAR, V11, P1513

[6]

Goode EL, 2003, CANCER EPIDEM BIOMAR, V12, P1119

[7]

Ishitobi M, 2003, CLIN CANCER RES, V9, P1376

[8] A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers [J].

Kadouri, L ;

Kote-Jarai, Z ;

Hubert, A ;

Durocher, F ;

Abeliovich, D ;

Glaser, B ;

Hamburger, T ;

Eeles, RA ;

Peretz, T .

BRITISH JOURNAL OF CANCER, 2004, 90 (10) :2002-2005

[9] A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers [J].

Levy-Lahad, E ;

Lahad, A ;

Eisenberg, S ;

Dagan, E ;

Paperna, T ;

Kasinetz, L ;

Catane, R ;

Kaufman, B ;

Beller, U ;

Renbaum, P ;

Gershoni-Baruch, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3232-3236

[10] RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein [J].

Mizuta, R ;

LaSalle, JM ;

Cheng, HL ;

Shinohara, A ;

Ogawa, H ;

Copeland, N ;

Jenkins, NA ;

Lalande, M ;

Alt, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) :6927-6932