In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics

被引：27

作者：

Longman-Jacobsen, N ^{[1
]}

Williamson, JF ^{[1
]}

Dawkins, RL ^{[1
]}

Gaudieri, S ^{[1
]}

机构：

[1] Univ Western Australia, Ctr Mol Immunol & Instrumentat, Canning Vale South, WA 6155, Australia

来源：

GENE | 2003年 / 312卷

基金：

英国医学研究理事会;

关键词：

indels; single nucleotide polymorphisms (SNP)s; polymorphic blocks; quantum genomics; Major Histocompatibility Complex;

D O I：

10.1016/S0378-1119(03)00621-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：257 / 261

页数：5

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