Selection events operating at various stages in B cell development

被引：104

作者：

Rolink, AG ^{[1
]}

Schaniel, C ^{[1
]}

Andersson, J ^{[1
]}

Melchers, F ^{[1
]}

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(00)00205-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells have to progress through various checkpoints during their process of development. The three transcription factors E2A, EBF (early B cell factor) and Pax5 play essential roles in B cell commitment checkpoints. The various forms of the BCR and their downstream signaling molecules, which are expressed at different stages of B cell development, act as critical checkpoint guards allowing (positive selection) or preventing (negative selection) developmental progression. The recent advances on the molecular mechanisms operating at these various checkpoints are here summarized and discussed.

引用

页码：202 / 207

页数：6

共 62 条

[1] STIMULATION BY T-CELL INDEPENDENT ANTIGENS CAN RELIEVE THE ARREST OF DIFFERENTIATION OF IMMATURE AUTO-REACTIVE B-CELLS IN THE BONE-MARROW [J].