Hepatic encephalopathy

被引:24
作者
Ong, JP [1 ]
Mullen, KD [1 ]
机构
[1] Cleveland Clin Fdn, Dept Gastroenterol, Cleveland, OH 44195 USA
关键词
ammonia; benzodiazepine; cirrhosis; GABA; hepatic encephalopathy; pathogenesis; treatment;
D O I
10.1097/00042737-200104000-00005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In the last decade, a significant amount of research has been devoted to the pathogenesis and treatment of hepatic encephalopathy (HE), Non-invasive neuroimaging techniques such as magnetic resonance imaging and spectroscopy have become important research tools. The search for a suitable animal model of HE associated with cirrhosis is still ongoing, Moreover, consensus terminology and diagnostic criteria for HE in humans are badly needed, Eur J Gastroenterol Hepatol 13:325-334 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:325 / 334
页数:10
相关论文
共 170 条
[1]  
ALMARDINI H, 1993, HEPATOLOGY, V17, P1033
[2]   The effect of flumazenil on subclinical psychometric or neurophysiological alterations in cirrhotic patients: a double-blind placebo-controlled study [J].
Amodio, P ;
Marchetti, P ;
DelPiccolo, F ;
Beghi, A ;
Comacchio, F ;
Carraro, P ;
Campo, G ;
Baruzzo, L ;
Marchiori, C ;
Gatta, A .
CLINICAL PHYSIOLOGY, 1997, 17 (05) :533-539
[3]   Endogenous benzodiazepine activity in the peripheral and portal blood of dogs with congenital portosystemic shunts [J].
Aronson, LR ;
Gacad, RC ;
KaminskyRuss, K ;
Gregory, CR ;
Mullen, KD .
VETERINARY SURGERY, 1997, 26 (03) :189-194
[4]   Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of patients with liver cirrhosis with and without overt encephalopathy [J].
Avallone, R ;
Zeneroli, ML ;
Venturini, I ;
Corsi, L ;
Schreier, P ;
Kleinschnitz, M ;
Ferrarese, C ;
Farina, F ;
Baraldi, C ;
Pecora, N ;
Frigo, M ;
Baraldi, M .
GUT, 1998, 42 (06) :861-867
[5]   Flumazenil for hepatic encephalopathy grade III and IVa in patients with cirrhosis: An Italian multicenter double-blind, placebo-controlled, cross-over study [J].
Barbaro, G ;
Di Lorenzo, G ;
Soldini, M ;
Giancaspro, G ;
Bellomo, G ;
Belloni, G ;
Grisorio, B ;
Annese, M ;
Bacca, D ;
Francavilla, R ;
Barbarini, G .
HEPATOLOGY, 1998, 28 (02) :374-378
[6]   Ammonia and GABA-ergic neurotransmission: Interrelated factors in the pathogenesis of hepatic encephalopathy [J].
Basile, AS ;
Jones, EA .
HEPATOLOGY, 1997, 25 (06) :1303-1305
[7]  
Bengtsson F, 1996, ADV EXP MED BIOL, V398, P387
[8]   AROMATIC AND BRANCHED-CHAIN AMINO-ACIDS IN AUTOPSIED BRAIN-TISSUE FROM CIRRHOTIC-PATIENTS WITH HEPATIC-ENCEPHALOPATHY [J].
BERGERON, M ;
LAYRARGUES, GP ;
BUTTERWORTH, RF .
METABOLIC BRAIN DISEASE, 1989, 4 (03) :169-176
[9]   REGIONAL ALTERATIONS OF DOPAMINE AND ITS METABOLITES IN RAT-BRAIN FOLLOWING PORTACAVAL ANASTOMOSIS [J].
BERGERON, M ;
SWAIN, MS ;
READER, TA ;
BUTTERWORTH, RF .
NEUROCHEMICAL RESEARCH, 1995, 20 (01) :79-86
[10]   Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: Implications for thymoleptic drug safety in liver insufficiency [J].
Bergqvist, PBF ;
Wikell, C ;
Hjorth, S ;
Apelqvist, G ;
Bengtsson, F .
CLINICAL NEUROPHARMACOLOGY, 1997, 20 (06) :511-522