Management of cisplatin-induced delayed emesis

被引:31
作者
Hesketh, P
机构
[1] Division of Hematology and Oncology, St. Elizabeth’s Medical Center, Boston, MA
关键词
delayed emesis; nausea; cisplatin; antiemetics; chemotherapy;
D O I
10.1159/000227644
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
High-dose cisplatin chemotherapy induces a biphasic pattern of emesis. Following the initial peak of emesis, which occurs during the first 8 h after cisplatin, there is a reduction in the occurrence of symptoms with a further increase in the incidence of nausea and emesis which are most severe 48-72 h following cisplatin administration. This latter phase of emesis is defined as delayed emesis and is distinct from the prolonged emesis which occurs after non-cisplatin chemotherapy such as cyclophosphamide. The incidence and severity of delayed emesis is influenced by the dose of cisplatin, being particularly severe in patients receiving doses >100 mg/m(2). Patients who have good control of acute emesis experience less delayed emesis. For this reason, clinical trials designed to evaluate antiemetics for delayed emesis should be carefully designed; ideally patients should be randomized to different treatments after the first 24 h. Studies which have used this design have shown that metoclopramide plus dexamethasone is an effective treatment. However, approximately 50% of patients may experience delayed emesis despite this treatment. The efficacy of the 5-HT3 receptor antagonists in the control of cisplatin-induced delayed emesis in phase II studies has been equivocal and large well-controlled studies with these agents are needed to establish their role in this setting.
引用
收藏
页码:73 / 77
页数:5
相关论文
共 14 条
  • [1] Ondansetron Compared with High-Dose Metoclopramide in Prophylaxis of Acute and Delayed Cisplatin-Induced Nausea and Vomiting - A Multicenter, Randomized, Double-Blind, Crossover Study
    Demulder, PHM
    Seynaeve, C
    Vermorken, JB
    Vanliessum, PA
    Molsjevdevic, S
    Allman, EL
    Beranek, P
    Verweij, J
    [J]. ANNALS OF INTERNAL MEDICINE, 1990, 113 (11) : 834 - 840
  • [2] GANDARA DR, 1992, SEMIN ONCOL, V19, P67
  • [3] INCIDENCE, COURSE, AND SEVERITY OF DELAYED NAUSEA AND VOMITING FOLLOWING THE ADMINISTRATION OF HIGH-DOSE CISPLATIN
    KRIS, MG
    GRALLA, RJ
    CLARK, RA
    TYSON, LB
    OCONNELL, JP
    WERTHEIM, MS
    KELSEN, DP
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1985, 3 (10) : 1379 - 1384
  • [4] CONTROLLING DELAYED VOMITING - DOUBLE-BLIND, RANDOMIZED TRIAL COMPARING PLACEBO, DEXAMETHASONE ALONE, AND METOCLOPRAMIDE PLUS DEXAMETHASONE IN PATIENTS RECEIVING CISPLATIN
    KRIS, MG
    GRALLA, RJ
    TYSON, LB
    CLARK, RA
    CIRRINCIONE, C
    GROSHEN, S
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (01) : 108 - 114
  • [5] KRIS MG, 1992, CANCER, V70, P1012
  • [6] COMPARISON OF THE 5-HYDROXYTRYPTAMINE3 (SEROTONIN) ANTAGONIST ONDANSETRON (GR-38032F) WITH HIGH-DOSE METOCLOPRAMIDE IN THE CONTROL OF CISPLATIN-INDUCED EMESIS
    MARTY, M
    POUILLART, P
    SCHOLL, S
    DROZ, JP
    AZAB, M
    BRION, N
    PUJADELAURAINE, E
    PAULE, B
    PAES, D
    BONS, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (12) : 816 - 821
  • [7] INCIDENCE OF NAUSEA AND VOMITING WITH CYTOTOXIC CHEMOTHERAPY - PROSPECTIVE RANDOMIZED TRIAL OF ANTI-EMETICS
    MORRAN, C
    SMITH, DC
    ANDERSON, DA
    MCARDLE, CS
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1979, 1 (6174): : 1323 - 1324
  • [8] DOUBLE-BLIND, RANDOMIZED TRIAL FOR THE CONTROL OF DELAYED EMESIS IN PATIENTS RECEIVING CISPLATIN - COMPARISON OF PLACEBO VS ADRENOCORTICOTROPIC HORMONE (ACTH)
    PASSALACQUA, R
    COCCONI, G
    BELLA, M
    MONICI, L
    MICHIARA, M
    BANDINI, N
    BACCHI, M
    [J]. ANNALS OF ONCOLOGY, 1992, 3 (06) : 481 - 485
  • [9] ROILA F, 1992, LANCET, V340, P96
  • [10] PREDICTIVE FACTORS OF DELAYED EMESIS IN CISPLATIN-TREATED PATIENTS AND ANTIEMETIC ACTIVITY AND TOLERABILITY OF METOCLOPRAMIDE OR DEXAMETHASONE - A RANDOMIZED SINGLE-BLIND STUDY
    ROILA, F
    BOSCHETTI, E
    TONATO, M
    BASURTO, C
    BRACARDA, S
    PICCIAFUOCO, M
    PATOIA, L
    SANTI, E
    PENZA, O
    BALLATORI, E
    DELFAVERO, A
    [J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1991, 14 (03): : 238 - 242