MALDI-TOF mass spectrometry - A versatile tool for high-performance DNA analysis

被引：146

作者：

Jurinke, C ^{[1
]}

Oeth, P ^{[1
]}

van den Boom, D ^{[1
]}

机构：

[1] Sequenom Inc, San Diego, CA 92121 USA

来源：

MOLECULAR BIOTECHNOLOGY | 2004年 / 26卷 / 02期

关键词：

MALDI-TOF; SNP analysis; genotyping; quantitative MALDI-TOF; gene-expression analysis; resequencing; SNP discovery; DNA pooling;

D O I：

10.1385/MB:26:2:147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has developed during the past decade into a versatile tool for biopolymer analysis. The aim of this review is to summarize this development and outline the applications, which have been enabled for routine use in the field of nucleic acid analysis. These include the analysis of mutations, the resequencing of amplicons with a known reference sequence, and the quantitative analysis of gene expression and allelic frequencies in complex DNA mixtures.

引用

页码：147 / 163

页数：17

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