PK1/EG-VEGF induces monocyte differentiation and activation

被引：87

作者：

Dorsch, M ^{[1
]}

Qiu, YB ^{[1
]}

Soler, D ^{[1
]}

Frank, N ^{[1
]}

Duong, T ^{[1
]}

Goodearl, A ^{[1
]}

O'Neil, S ^{[1
]}

Lora, J ^{[1
]}

Fraser, CC ^{[1
]}

机构：

[1] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2005年 / 78卷 / 02期

关键词：

macrophage; innate; Th1; cytokine;

D O I：

10.1189/jlb.0205061

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macrophages exist as sentinels in innate immune response and react by expressing proinflammatory cytokines and up-regulating antigen-presenting and costimulatory molecules. We report a novel function for prokineticin-1 (PK1)/endocrine gland-derived vascular endothelial growth factor. Screening of murine tissue sections and cells for specific binding site leads to the identification of macrophages as an in vivo cellular target for PK1. We demonstrate PK1 induces differentiation of murine and human bone marrow cells into the monocyte/ macrophage lineage. Human peripheral blood monocytes respond to PK1 by morphological changes and down-regulation of B7-1, CD14, CC chemokine receptor 5, and CXC chemokine receptor 4. Monocytes treated with PK1 have elevated interleukin (IL)-12 and tumor necrosis factor alpha and down-regulated IL-10 production in response to lipopolysaccharide. PK1 induces a distinct monocyte-derived cell population, which is primed for release of proinflammatory cytokines that favor a T helper cell type 1 response.

引用

页码：426 / 434

页数：9

共 41 条

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